Race-Based Measurements of eGFR

Every time you get routine blood work done, one test measures your kidney function, using an indicator called eGFR. This number helps doctors assess how well your kidneys are filtering waste from your blood. But eGFR uses race based measurements, which many physicians agree is outdated and harmful. 

eGFR stands for estimated Glomerular Filtration Rate. Think of your kidneys as tiny filters working behind the scenes, removing waste products from your blood. eGFR gives doctors an idea of how efficiently those filters are working. It’s crucial for diagnosing and managing conditions like chronic kidney disease (CKD).

Traditionally, eGFR calculations included a factor based on a person’s race. The idea was that people of certain races, usually Black individuals, might have higher creatinine levels due to factors like muscle mass. This meant their eGFR could be slightly lower, even if their kidneys were functioning normally.

However, here’s the problem: there’s no scientific evidence that race is a reliable indicator of kidney function. In fact, social and environmental factors, like socioeconomic status and access to healthcare, play a much larger role in kidney health disparities.

Using race in eGFR calculations can lead to inaccurate diagnoses, especially for Black individuals. Their eGFR might be overestimated, potentially delaying crucial diagnoses and access to treatment for CKD. This can worsen health outcomes and contribute to existing healthcare disparities.

The good news is that there are ongoing efforts to address this issue. This includes Race-free eGFR equations. Researchers are developing and validating new eGFR formulas that exclude race as a factor. These equations rely on different markers and require further testing, but they hold promise for more accurate assessments.

The issue of race and eGFR is complex and requires ongoing research, dialogue, and action. Moving towards more accurate and equitable approaches in healthcare can help ensure everyone receives fair and timely diagnoses and treatment, regardless of their race or background. Remember, open communication with your doctor is key to understanding your specific health situation and getting the best possible care.

Sources 

1.  Mayo Clinic Laboratories. “Estimated Glomerular Filtration Rate (eGFR).” Mayo Clinic https://www.mayocliniclabs.com/test-catalog/overview/48216.

2.  National Kidney Foundation. “KDOQI Guidelines.” National Kidney Foundation https://www.kidney.org/professionals/KDOQI/gfr.

3.  National Kidney Foundation. “Social Determinants of Health and Chronic Kidney Disease.” National Kidney Foundation https://www.kidney.org/atoz/content/social-determinants-health-and-chronic-kidney-disease.

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